Protein Spotlight 219

A Spotlight on Spotlight

In this paper, we have made an attempt to take a look under the hood of Spotlight and understand some of the following questions amongst others: • How well-integrated is Spotlight with the file system? • How reliable is the interface between Spotlight and the file system? • Is live update a myth or a reality under heavy file system activity? Based on our experiments, it seems that Spotlight is ...

Lecture Notes for Ph 219 / CS 219 : Quantum Information

Dev126326 219..231

Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyperactivation of Notch in larval neuroblasts leads to tumours, we combined results from profiling the upregulated m...

Dmd067868 209..219

The thiouracil derivative PF-06282999 [2-(6-(5-chloro-2-methoxyphenyl)4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide] is an irreversible inactivator of myeloperoxidase and is currently in clinical trials for the potential treatment of cardiovascular diseases. Concerns over idiosyncratic toxicity arising from bioactivation of the thiouracil motif to reactive species in the liver have bee...

C1lc20678h 219..226

In this work, we developed a microfluidic device for the imitation of drug metabolism in human liver and its cytotoxicity on cells. The integrated microfluidic device consists of three sections: (1) bioreactors containing poly(ethylene) glycol (PEG) hydrogel encapsulated human liver microsomes (HLMs); (2) cell culture chambers for cytotoxicity assay; and (3) integrated micro solid-phase extract...